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Chlorphenamine / Promethazine / Diphenhydramine
SACAA Part 67 assessment
Not acceptable / incompatible with flying duties
Active ingredient(s)
Chlorphenamine / Promethazine / Diphenhydramine
First-generation (sedating) antihistamine
Typical grounding period: 24–48 hours
Measured from the last dose, and only once completely side-effect free.
Guidance notes
Markedly sedating with long-lasting subtle performance impairment. Not acceptable for flying. If taken, remain grounded at least 24–48 hours after the last dose.
Known SA brand names
Contact a professional
Our partner Buchner Med can assist with aviation medical assessments and DAME consultations. Alternatively, find an SACAA-certified DAME directly through the official list.
Possible acceptable alternatives (same therapeutic group)
- LoratadineClarityne, Lorano, Allergex Non-DrowsyAcceptable
- FexofenadineTelfast, FexoAcceptable
- CetirizineZyrtec, Texa, AllecetConditional
Alternatives are informational only. The underlying medical condition must also be assessed by a DAME — a condition can ground you even when the medicine is acceptable.