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H2 receptor antagonists (Cimetidine, Ranitidine, Famotidine)

SACAA Part 67 assessment

Acceptable with conditions / grounding period

Active ingredient(s)

H2 receptor antagonists (Cimetidine, Ranitidine, Famotidine)

Acid suppression — H2 antagonist

Typical grounding period: 12 hours

Measured from the last dose, and only once completely side-effect free.

Guidance notes

Cimetidine is allowed only if taken more than 8 hours before aviation activity; ranitidine only if taken more than 12 hours before. A proton pump inhibitor such as omeprazole is generally the preferred acceptable option.

Known SA brand names

CimetidineTagametRanitidineZantacFamotidine

Our DAME partners

SACAA certified DAME list

Possible acceptable alternatives (same therapeutic group)

Alternatives are informational only. The underlying medical condition must also be assessed by a DAME — a condition can ground you even when the medicine is acceptable.

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SACAA Aviation Medicine (official reference)