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Loperamide

SACAA Part 67 assessment

Acceptable with conditions / grounding period

Active ingredient(s)

Loperamide

Anti-diarrhoeal

Typical grounding period: 6 hours

Measured from the last dose, and only once completely side-effect free.

Guidance notes

Table A1: loperamide must not be taken less than 6 hours before aviation activity. Opioid-based antidiarrhoeals (codeine phosphate, morphine, Lomotil) are unacceptable. Acute gastroenteritis with dehydration grounds the crew member until resolved.

Category rules that also apply

Controlled / narcotic substance — absolute prohibition

Narcotics, opioids, sedatives of dependence and stimulants of abuse (Schedule 5 and 6 medicines, and all illicit substances) are incompatible with aviation duty. No flying, air traffic control or cabin crew duty while the substance is being used, and return to duty requires formal DAME assessment of the medicine, the underlying condition and any dependence risk — not simply a washout period. These substances also trigger positive results on SACAA and operator substance screening, which carries licensing consequences separate from the medical assessment. Never combine them with alcohol.

Known SA brand names

ImodiumLopediumDiaremLoperamide

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SACAA Aviation Medicine (official reference)