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Promethazine
Part of group: First-generation (sedating) antihistamine
SACAA Part 67 assessment
Not acceptable / incompatible with flying duties
Active ingredient(s)
3 in groupFirst-generation (sedating) antihistamine
Typical grounding period: 48 hours (2 days)
Measured from the last dose, and only once completely side-effect free.
Guidance notes
Markedly sedating with long-lasting subtle performance impairment. Not acceptable for flying. If taken, remain grounded at least 24–48 hours after the last dose.
Known SA brand names
Our DAME partners
Dr Berlize du Plessis
Senior DAME · MS213
Kenridge, Cape Town
Dr Brandon Head
Senior DAME · MS229
Sunninghill, Sandton
Dr Ernest Schutz
Senior DAME · MS028
Germiston
Dr Mariska van Tonder
Senior DAME · MS222
Somerset West
Dr Richard Albrecht
Senior DAME · MS074
Strubensvalley, Roodepoort
Dr. Schalk Reyneke
Senior DAME · MS123
Honeydew, Roodepoort
Possible acceptable alternatives (same therapeutic group)
- LoratadineClarityne, Lorano, Allergex Non-DrowsyAcceptable
- FexofenadineTelfast, Fexo, FexofenAcceptable
- CetirizineZyrtec, Texa, AllecetConditional
Alternatives are informational only. The underlying medical condition must also be assessed by a DAME — a condition can ground you even when the medicine is acceptable.