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SACAA Part 67 medication guidance · unofficial

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Co-phenotrope (diphenoxylate with atropine), Codeine phosphate, Aminopentamide

SACAA Part 67 assessment

Not acceptable / incompatible with flying duties

Active ingredient(s)

Co-phenotrope (diphenoxylate with atropine), Codeine phosphate, Aminopentamide

Anti-diarrhoeal — opioid / anticholinergic

Guidance notes

Unacceptable for aviation duty — these combine an opioid with an anticholinergic. Loperamide is the acceptable alternative, provided it is not taken less than 6 hours before aviation activity.

Category rules that also apply

Controlled / narcotic substance — absolute prohibition

Narcotics, opioids, sedatives of dependence and stimulants of abuse (Schedule 5 and 6 medicines, and all illicit substances) are incompatible with aviation duty. No flying, air traffic control or cabin crew duty while the substance is being used, and return to duty requires formal DAME assessment of the medicine, the underlying condition and any dependence risk — not simply a washout period. These substances also trigger positive results on SACAA and operator substance screening, which carries licensing consequences separate from the medical assessment. Never combine them with alcohol.

Known SA brand names

LomotilCo-phenotropeDiphenoxylateCodeine phosphateAminopentamide

Our DAME partners

SACAA certified DAME list

Possible acceptable alternatives (same therapeutic group)

Alternatives are informational only. The underlying medical condition must also be assessed by a DAME — a condition can ground you even when the medicine is acceptable.

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SACAA Aviation Medicine (official reference)